The formin FMNL2 plays a role in the response of melanoma cells to substrate stiffness.

ABSTRACT:

Background

Cells constantly sense and respond to changes in their local environment to adapt their behaviour and morphology. These external stimuli include chemical and mechanical signals, and much recent work has revealed the complexity of the cellular response to changes in substrate stiffness. We investigated the effects of substrate stiffness on the morphology and motility of A2058 human melanoma cells. FMNL2, a formin protein associated with actin cytoskeleton dynamics, regulates melanoma cell morphology and motility, but its role in stiffness sensing remains unclear. This study examines how A2058 cells respond to substrates of varying stiffness and evaluates the impact of FMNL2 depletion on these responses.

Results

We found that with increasing substrate stiffness the

SUBMITTER: Clugston JD 

PROVIDER: S-EPMC12039054 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature