Mechanisms of HRAS regulation of liver hepatocellular carcinoma for prognosis prediction.

ABSTRACT:

Background

Liver hepatocellular carcinoma (LIHC) often has a poor prognosis. Since the relationship between HRas proto-oncogene, GTPase (HRAS) and LIHC has not been elucidated, the aim of this study was to explore the mechanisms by which HRAS is involved in regulating the prognosis of LIHC.

Methods

We usedThe Cancer Genome Atlas (TCGA) database to characterize differences in HRAS gene expression between LIHC patients and healthy individuals. In addition, we analysed the relationships between HRAS gene expression levels and the clinicopathological characteristics of LIHC patients. Next, we used univariate and multivariate Cox regression analyses to identify prognostic factors. Differentially expressed genes were identified between the low- and high-expression groups, and KEGG

SUBMITTER: Fang X 

PROVIDER: S-EPMC12039069 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature