ERβ mediates sex-specific protection in the App-NL-G-F mouse model of Alzheimer's disease.

ABSTRACT:

Background

Menopausal loss of neuroprotective estrogen is thought to contribute to the sex differences in Alzheimer's disease (AD). Activation of estrogen receptor beta (ERβ) can be clinically relevant since it avoids the adverse systemic effects of ERα activation. However, very few studies have explored ERβ-mediated neuroprotection in AD, and no information on its contribution to the sex differences in AD exists. In the present study, we specifically explored the role of ERβ in mediating sex-specific protection against AD pathology in the App^NL-G-F knock-in mouse model of amyloidosis, and if surgical menopause (ovariectomy) modulates pathology in this model.

Methods

We treated male and female App^NL-G-F knock-in mice with the clinically relevant and sel

SUBMITTER: Demetriou A 

PROVIDER: S-EPMC12039102 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature