Zapotin mitigates breast cancer progression by targeting PKCε mediated glycolytic pathway regulation.

ABSTRACT:

Background

The breast cancer recurrence and chemoresistance has increased over the years. A novel PKC, PKCε, may promote chemoresistance by causing hypoxia and cancer metabolic rewiring. A natural flavonoid, Zapotin, in colon cancer cells may modulate PKCε expression. Therefore, this study aimed to explore Zapotin impact on PKCε expression and the metabolic profile of breast cancer cells.

Methods

Pharmacophore analysis of Zapotin was performed and molecular dynamics (MD) simulations were employed to study PKCε and Zapotin interaction stability. The effect of Zapotin treatment on PKCε expression and various aspects of cancer cell viability and metabolism was studied in MCF-7 and MDA-MB-231 breast cancer cell lines using real-time PCR, growth and death assays, and Gas Chromato

SUBMITTER: Khan K 

PROVIDER: S-EPMC12039207 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature