Metabolic dysfunction-associated steatotic liver disease, metabolic alcohol-related liver disease, and incident dementia: a nationwide cohort study : MASLD, MetALD, and dementia risk.

ABSTRACT:

Background

The relationship between the newly proposed steatotic liver disease (SLD) subtypes-metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic alcohol-associated liver disease (MetALD)-and dementia is understudied. We evaluated the dementia risk associated with these subtypes.

Methods

This retrospective cohort study included 296,001 participants aged over 60 who underwent health examinations between 2009 and 2010. Participants were categorized into non-SLD (reference), MASLD, and MetALD groups and followed up until dementia onset, death, or December 31, 2019. SLD was defined by a fatty liver index ≥ 30, with (i) MASLD based on cardiometabolic risk factors, and (ii) MetALD as MASLD with moderate alcohol intake. Outcomes included overall dementia,

SUBMITTER: Shin WY 

PROVIDER: S-EPMC12039214 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature