Inhibition of ALKBH5 demethylase of m⁶A pathway potentiates HIV-1 reactivation from latency.

ABSTRACT:

Background

Current latency-reversing agents (LRAs) employed in the "shock-and-kill" strategy primarily focus on relieving epigenetic and transcriptional blocks to reactivate the latent HIV-1. However, their clinical efficacy is limited, partly due to their inability to fully reverse latency and the lack of LRAs specifically targeting post-transcriptional mechanisms. N6-methyladenosine (m⁶A) modification in HIV-1 RNA is emerging as an important post-transcriptional regulator of HIV-1 gene expression, yet its role in latency and reactivation remains largely unrecognized. Here, we explored the potential of small chemical compounds targeting the m⁶A pathway, specifically investigating the inhibition of ALKBH5 and its effect on latent HIV-1 reactivation mediated by

SUBMITTER: Ali H 

PROVIDER: S-EPMC12039216 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature