The essential kinase TgGSK regulates centrosome segregation and endodyogeny in <i>Toxoplasma gondii</i>.

ABSTRACT: Intracellular replication is crucial for the success of apicomplexan parasites, including Toxoplasma gondii. Therefore, essential players in parasite replication represent potential targets for drug development. We have characterized TgGSK, a glycogen synthase kinase homolog that plays an important role in Toxoplasma endodyogeny. We have shown that TgGSK has a dynamic localization that is concurrent with the cell cycle. In non-dividing parasites, this kinase is highly concentrated in the nucleus. However, during division, TgGSK displays a cytosolic localization, with concentration foci at the centrosomes, a key organelle involved in parasite division, and the basal end. Conditional knockdown of TgGSK determined that it is essential for the completion of the lytic cycle and pr

SUBMITTER: Krueger A 

PROVIDER: S-EPMC12039231 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature