Methods to evaluate the performance of a multicomponent meningococcal serogroup B vaccine.

ABSTRACT: Meningococcal serogroup B (MenB) vaccine licensure was based on the assessment of vaccine-induced immune responses by human serum bactericidal antibody (hSBA) assay against a small number of antigen-specific strains complemented by strain coverage predictions. However, the evaluation of vaccine strain coverage is challenging because of genotypic and phenotypic diversity in surface-exposed MenB strain antigens. This narrative review considers the principal methods applied to assess the performance of a multicomponent MenB vaccine at different stages of its development. Traditional hSBA assay against a limited panel of strains is useful at all stages, while predicted strain coverage methods, such as the meningococcal antigen typing system, are used independent of clinical trials. A new metho

SUBMITTER: Borrow R 

PROVIDER: S-EPMC12039234 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature