Toxoplasmosis accelerates the progression of hereditary spastic paraplegia.

ABSTRACT: The parasitic protozoa Toxoplasma gondii chronically infects the central nervous system of an estimated one-third of the human population. Infection is generally subclinical, but immunocompromised individuals can experience a variety of neurological symptoms. Meta-analyses of T. gondii seropositivity have suggested a correlation between T. gondii infection and neurologic disease. Although mechanistic studies on the relationship between T. gondii infection and neurologic disease have been attempted in mice, they are particularly susceptible to T. gondii, making them an effective model for investigating mechanisms of infection, but not ideal for examining the relationship between long-term chronic T. gondii infection and neurologic disease. Rats more

SUBMITTER: Alvin JR 

PROVIDER: S-EPMC12039240 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature