The Gcn5 lysine acetyltransferase mediates cell wall remodeling, antifungal drug resistance, and virulence of <i>Candida auris</i>.

ABSTRACT: Candida auris has emerged as a multidrug-resistant human fungal pathogen that causes infections of high morbidity and mortality. However, the molecular mechanisms underlying pronounced multidrug resistance and host-pathogen interactions are poorly understood. Here, we show that C. auris GCN5 lysine acetyltransferase is essential for cell wall remodeling, antifungal drug resistance, and virulence. The Candida albicans GCN5 has previously been shown to be an important regulator of antifungal drug resistance and virulence. Therefore, to identify Gcn5-dependent evolutionary conserved as well as divergent transcriptional networks between the two species, we performed comparative transcriptional analysis. The gene set enrichment analysis of C. auris vs C. albicans

SUBMITTER: Chauhan M 

PROVIDER: S-EPMC12039264 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature