Tuberculosis among young contacts of patients with multidrug-resistant pulmonary tuberculosis in a reference hospital.

ABSTRACT:

Objectives

Young contacts of pulmonary tuberculosis (TB) patients face a higher risk of TB. Still, few studies have evaluated this risk among contacts of patients with pulmonary multidrug-resistant tuberculosis (MDR-TB). This study aimed to describe the incidence rate and the prevalence of TB infection (TBI) and TB disease (TBD) in young contacts of patients with MDR-TB.

Methods

The authors retrospectively evaluated contacts of patients with pulmonary TB aged 0 to 19 for TBI and TBD in Rio de Janeiro between 2006 and 2016. Based on the drug susceptibility pattern and/or therapeutic regimen of the index case, contacts were classified into MDR-TB and non-MDR-TB contacts. A tuberculin skin test ≥ 5 mm was considered positive. Preventive therapy with isoniazid was offered to eli

SUBMITTER: Rubin EF 

PROVIDER: S-EPMC12039512 | biostudies-literature | 2025 May-Jun

REPOSITORIES: biostudies-literature