Analysis of metabolic differences in Tibetan medicinal plant <i>Phlomoides rotata</i> leaves in different habitats based on non-targeted metabolomics.

ABSTRACT: Phlomoides rotata, a traditional Tibetan medicinal herb renowned for its anti-inflammatory and analgesic properties, exhibits distinct metabolite profiles across heterogeneous environments. However, the impacts of altitude and slope orientation on its secondary metabolism remain poorly understood. This study aimed to characterize metabolite variations in the leaves of Phlomoides rotata under different elevations and microclimates, providing a mechanistic basis for its quality evaluation and sustainable utilization. Metabolomic analysis was conducted using ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-MS). Leaf samples were collected from three altitude gradients (4,300 m, 4,600 m, 5,000 m) and two slope orientations (south vs. no

SUBMITTER: Wang L 

PROVIDER: S-EPMC12039763 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature