Distinct Clinical Features of Extrapulmonary and Disseminated Tuberculosis in HIV- and Non-HIV-Associated Immunosuppression: A Retrospective Cohort Study.

ABSTRACT:

Background

There is scarce information regarding the clinical differences between extrapulmonary and disseminated tuberculosis (TB) in patients with different types of immunosuppression. We aimed to compare the clinical characteristics and outcomes of extrapulmonary and disseminated TB in patients with non-human immunodeficiency virus (HIV)-associated and HIV-associated immunocompromise.

Methods

In this retrospective cohort study, we included immunocompromised adults with extrapulmonary or disseminated TB in a referral center in Mexico City from January 2000 to December 2023. We compared clinical characteristics, treatments, and death. Multivariate logistic regression analysis for death-related characteristics and Kaplan-Meier survival estimates were performed.

Results

SUBMITTER: Aceves-Sanchez B 

PROVIDER: S-EPMC12039804 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature