Lateral thinking: Neurodegeneration of the cortical cholinergic system in Alzheimer's disease.

ABSTRACT:

Introduction

Atrophy of the nucleus basalis of Meynert (NBM) is an early indicator of Alzheimer's disease (AD). However, reduced integrity of the NBM white matter tracts may be more relevant for cognitive impairment and progression to dementia than NBM volume. Research is needed to compare differences in NBM volume and integrity of the lateral and medial NBM tracts across early and later stages of AD progression.

Methods

187 participants were included in this study who were either healthy controls (HC; n = 50) or had early mild cognitive impairment (EMCI; n = 50), late MCI (LMCI; n = 37), or AD (n = 50). NBM volume was calculated using voxel-based morphometry and mean diffusivity (MD) of the lateral and medial NBM tracts were extracted using probabilistic tractography. Betwe

SUBMITTER: Crockett RA 

PROVIDER: S-EPMC12039838 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature