Prospective randomized trial comparing conventional and underwater endoscopic submucosal dissection for superficial colorectal neoplasms.

ABSTRACT: This study compared procedure-related outcomes of conventional and underwater endoscopic submucosal dissection (ESD) for superficial colorectal neoplasms (SCNs).In this single-center, randomized controlled trial, patients with SCNs meeting the indications of the Japanese guidelines for ESD were randomly assigned to undergo conventional ESD (CESD) or underwater ESD (UESD) performed by an expert. The primary endpoint was dissection speed, defined as the specimen area per ESD time.We analyzed the data of 69 and 70 CESD and UESD cases, respectively; however, no significant differences were found in median dissection speed (17.4 and 19.9 mm²/min, respectively; P=0.19). Multiple regression analysis revealed that the suitable positional relationship between the lesion and the di

SUBMITTER: Nagata M 

PROVIDER: S-EPMC12039920 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature