The relationship between infectious pathogen antibodies, plasma metabolites, and breast cancer: A Mendelian randomization study with mediation analysis.

ABSTRACT: Breast cancer (BC) has the second highest incidence rate among women worldwide. Although there are various treatment methods, the prognosis is poor once metastasis occurs. However, the extent to which pathogens of infectious diseases influence the risk of BC remains unclear. The goal of this study is to determine if these pathogens are causally related to BC development. A Mendelian randomization (MR) analysis is used to assess the causal relationship between infectious pathogen antibodies and the risk of BC, as well as their potential intermediary factors. Two-sample MR analysis using inverse variance weighting (IVW) is conducted to determine the causal relationship between infectious pathogen antibodies and the risk of BC. Additionally, the mediating role of 1400 metabolites between infe

SUBMITTER: Wei J 

PROVIDER: S-EPMC12040016 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature