Damage of the Phospholipid Bilayer by Aβ42 at Physiologically Relevant Peptide Concentrations.

ABSTRACT: Amyloid β (Aβ) aggregates are implicated in the pathology of several neurodegenerative diseases such as Alzheimer's disease, Huntington's disease, and Parkinson's disease, and damage to membranes is considered one of the pathology-related effects of Aβ. Experiments in vitro indicate that Aβ can damage these membranes; however, such experiments were performed at Aβ concentrations in the micromolar range, several orders above the physiologically relevant conditions. Our studies with Aβ42 in the low nanomolar concentrations did not reveal any damage to the supported lipid bilayer, questioning this membrane damage mechanism of Aβ. However, the phospholipid composition can be a factor contributing to the interaction of Aβ with the membrane. Therefore, in this study, we investigated the interact

SUBMITTER: van Deventer R 

PROVIDER: S-EPMC12040073 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature