A modified rat model of 8 minutes asphyxial cardiac arrest and cardiopulmonary resuscitation.

ABSTRACT: The animal model of cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) serves as a crucial tool for investigating the pathophysiology and treatment strategies associated with cardiac arrest, however, standardized procedures for such models remain insufficiently established. We aimed to modify and specify the existing rat model of asphyxial CA and CPR while providing an analysis of long-term outcomes.A total of 46 rats were allocated into two groups,sham and CA group.In CA group, cardiac arrest was induced through 8 minutes of hypoxia prior to the administration of CPR. In sham group, only tracheal intubation and vascular catheterization were conducted under isoflurane anesthesia. Key parameters along with arterial blood gas results during modeling were meticulously recorded. After

SUBMITTER: Liu X 

PROVIDER: S-EPMC12040107 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature