Impact of antiplatelet therapy on outcomes of sepsis: A systematic review and meta-analysis.

ABSTRACT:

Objective

Antiplatelet therapy has been studied for its potential benefits in various cardiovascular conditions, but its role in sepsis remains less clear. This review aims to systematically analyse the available evidence on the effects of antiplatelet therapy in sepsis to assess its potential benefits and risks.

Material and methods

The studies published until 01st April 2024 from PubMed, Embase and Scopus databases were searched. Pooled effect sizes were reported as relative risks (RR) or weighted mean difference (WMD) with corresponding 95% confidence intervals (CI). Outcomes included mortality, length of intensive care unit (ICU) stay, hospital stay, and the risk of complications. The certainty of evidence was evaluated using GRADE.

Results

Twenty-one studies were

SUBMITTER: Wang X 

PROVIDER: S-EPMC12040142 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature