Fluid and solute transport by cells and a model of systemic circulation.

ABSTRACT: Active fluid circulation and solute transport are essential functions of living organisms, enabling the efficient delivery of oxygen and nutrients to various physiological compartments. Since fluid circulation occurs in a network, the systemic flux and pressure are not simple outcomes of individual components. Rather, they are emergent properties of network elements and network topology. Moreover, consistent pressure and osmolarity gradients are maintained across compartments such as the kidney, interstitium, and blood vessels. The mechanisms by which these gradients and network properties are established and maintained are unanswered questions in systems physiology. Previous studies have shown that epithelial cells are fluid pumps and can actively generate pressure and osmolarity gradient

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12040233 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature