Expansion of myeloid suppressor cells and suppression of Lassa virus-specific T cells during fatal Lassa fever.

ABSTRACT: Lassa fever is a highly lethal hemorrhagic fever endemic to West Africa. In the absence of efficient prophylactic or therapeutic countermeasures, it poses a substantial threat to public health in this region. The pathophysiological mechanisms underlying the severity of the disease are poorly known because Lassa virus (LASV), its causative agent, has to be handled in BSL-4 laboratories and access to clinical samples is difficult. The control of Lassa fever is associated with a rapid and well-balanced immune response and viral clearance. However, severe disease is characterized by uncontrolled innate immune activation and symptoms reminiscent of sepsis and a cytokine storm. In a model of cynomolgus monkeys infected with two different strains of the virus, one causing moderate disease and the

SUBMITTER: Lafoux B 

PROVIDER: S-EPMC12040235 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature