Excellent Response to Trastuzumab Deruxtecan of a Large Medullary Metastasis from Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer: A Case Report.

ABSTRACT:

Introduction

Brain metastasis is a serious complication in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Brainstem metastases are particularly challenging to treat because of the high risks associated with surgery and stereotactic radiosurgery (SRS).

Case presentation

We present a case of a 56-year-old woman with HER2-positive breast cancer who developed multiple brain metastases, including a large medullary lesion, 9 months after surgery confirming a pathological complete response to standard trastuzumab plus pertuzumab-based neoadjuvant chemotherapy, without extracranial lesions. Surgery was deemed infeasible because the lesion's location and size posed high risks of toxicity from SRS. Promising intracranial responses to trastuzumab deruxtecan (T-

SUBMITTER: Kuroda A 

PROVIDER: S-EPMC12040302 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature