Bayesian Inference of Pathogen Phylogeography using the Structured Coalescent Model.

ABSTRACT: Over the past decade, pathogen genome sequencing has become well established as a powerful approach to study infectious disease epidemiology. In particular, when multiple genomes are available from several geographical locations, comparing them is informative about the relative size of the local pathogen populations as well as past migration rates and events between locations. The structured coalescent model has a long history of being used as the underlying process for such phylogeographic analysis. However, the computational cost of using this model does not scale well to the large number of genomes frequently analysed in pathogen genomic epidemiology studies. Several approximations of the structured coalescent model have been proposed, but their effects are difficult to predict. Here we

SUBMITTER: Roberts I 

PROVIDER: S-EPMC12040344 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature