Clinical impact and safety of brain biopsy in unexplained central nervous system disorders: a real-world cohort study.

ABSTRACT:

Objective

A substantial part of central nervous system (CNS) disorders remains unexplained, despite various new and minimally invasive diagnostic techniques. Within this rapidly developing diagnostic field, the precise role of brain biopsy is unknown. We aimed to study the clinical impact and safety of brain biopsies in unexplained CNS disorders.

Methods

In this retrospective cohort study, we included all adult patients who were referred for a diagnostic work-up to our academic center with neuro-inflammatory, neuro-oncological, and neuro-infectious expertise and underwent a brain biopsy between January 2010 and December 2023. Typical cases of CNS neoplasms and infections were not analyzed. Brain biopsies were evaluated with respect to diagnostic and therapeutic impact and co

SUBMITTER: van Steenhoven RW 

PROVIDER: S-EPMC12040505 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature