Amygdala Neurodegeneration: A Key Driver of Visual Dysfunction in Parkinson's Disease.

ABSTRACT:

Objective

Visual disability in Parkinson's disease (PD) is not fully explained by retinal neurodegeneration. We aimed to delineate the brain substrate of visual dysfunction in PD and its association with retinal thickness.

Methods

Forty-two PD patients and 29 controls underwent 3-Tesla MRI, retinal spectral-domain optical coherence tomography, and visual testing across four domains. Voxel-level associations between gray matter volume and visual outcomes were used to define a visual impairment region (visualROI). Functional connectivity of the visualROI with brain networks was analyzed. Covariance analysis of brain regions associated with retinal thinning (retinalROI) was conducted using hierarchical clustering to develop a model of retinal and brain neurodegeneration linked

SUBMITTER: Erramuzpe A 

PROVIDER: S-EPMC12040507 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature