Unraveling Leishmania major Metacyclogenesis: A Comprehensive Analysis of Transcriptomic

ABSTRACT:

Background

Metacyclogenesis is a critical developmental process in the life cycle of Leishmania parasites, particularly in their transition from non-infective procyclic to infective metacyclic promastigotes. This transformation is closely linked to the metabolic adaptation of the parasite, optimizing its survival and study, we integrated metabolomics and transcriptomics data to gain deeper molecular mechanisms of Leishmania major metacyclogenesis.

Methods

The metabolic profiles of procyclic and metacyclic promastigotes were first identified using ¹H-NMR spectroscopy. Multivariate statistical analysis conducted to distinguish different metabolites between the two forms. Metabolic pathway analysis was performed using the KEGG database to identify the metabolic pathways that si

SUBMITTER: Aminzadeh M 

PROVIDER: S-EPMC12040638 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature