The effect of curcumin supplementation on cognitive function: an updated systematic review and meta-analysis.

ABSTRACT:

Background

Previous randomized controlled trials (RCTs) did not draw a consistent conclusion about the effect of curcumin on cognitive function.

Methods

We searched Web of Science, PubMed, Cochrane Library and Embase, and 9 RCTs (including 12 independent comparisons) with 501 subjects were included in the present meta-analysis.

Results

Compared with placebo, supplementation of curcumin significantly improved global cognitive function (SMD, 0.82; 95% CI, 0.19 to 1.45; p = 0.010). A curvilinear dose-response effect was observed, and the optimal dose is 0.8 g/day. Subgroup analysis indicated that the beneficial effect of curcumin on cognition was significant only if duration ≥24 weeks (SMD, 1.15; 95% CI, 0.13 to 2.18; p = 0.027), age of participants ≥60 yea

SUBMITTER: Wang W 

PROVIDER: S-EPMC12040662 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature