Spatial-temporal interactions between white matter hyperintensities and multiple pathologies across the Alzheimer's disease continuum.

ABSTRACT:

Introduction

The interactive relationships between Alzheimer's disease (AD) and white matter hyperintensities (WMHs) in multiscale brain structural networks still need to be clarified.

Methods

Based on subjects enrolled from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, regional WMHs, amyloid beta (Aβ) accumulation, and microstructural changes detected by diffusion weighted imaging (DWI) in multiscale brain networks were modeled by time-evolving graphs; their interactive relationships were further investigated using Granger causality after constructing pseudo-time subject sequences.

Results

In up to 86% of the extracted pseudo-time subject sequences, Aβ was determined to be the Granger cause of WMHs in the structural connectivity of the inferior lon

SUBMITTER: Liang L 

PROVIDER: S-EPMC12040729 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature