Topology of gut Microbiota Network and Guild-Based Analysis in Chinese Adults.

ABSTRACT: Gut microbiota with co-abundant behaviors is considered belonging to the same guild in micro-ecosystem. In this study, we established co-abundance networks of operational taxonomic units (OTUs) among 2944 Chinese adults from the Shanghai Men's and Women's Health Studies and observed a positive connection-dominated scale-free network using Sparse Correlations for Compositional data (SparCC). The closeness centrality was negatively correlated with other degree-based topological metrics in the network, indicating the isolated modularization of the bacteria. A total of 130 guilds were constructed, with a high modularity of 0.68, and retaining more diversity of OTUs than genus classification. The scores of guild structure similarity for comparisons between all, the healthy and the unhealthy sub

SUBMITTER: Fu J 

PROVIDER: S-EPMC12040777 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature