Causal association between immune cell phenotypes and colorectal cancer: a two-sample bidirectional Mendelian randomization analysis.

ABSTRACT:

Background

Colorectal cancer (CRC) remains one of the leading causes of cancer-related death worldwide. Increasing evidence suggests that alterations in the immune system may play a pivotal role in the initiation and progression of CRC. However, the precise causal relationship between specific immune cell phenotypes and CRC remains incompletely understood. Elucidating this connection may unveil novel therapeutic targets for the treatment of CRC.

Methods

To explore the causal relationship between immune cell phenotypes and CRC, we conducted a comprehensive bidirectional Mendelian randomization (MR) analysis. Genetic variants were utilized as instrumental variables (IVs), with the inverse variance weighting (IVW) method employed to assess the effect of specific immune cell phe

SUBMITTER: Jiang W 

PROVIDER: S-EPMC12040795 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature