The impact of <i>BST1</i> rs4698412 variant on Parkinson's disease progression in a longitudinal study.

ABSTRACT:

Background

While the BST1 rs4698412 variant demonstrates a robust association with Parkinson's disease (PD) susceptibility, its role in modulating PD progression remains unexplored.

Objectives

To evaluate differences in the progression of motor symptoms and cognitive function between PD patients carrying the BST1 rs4698412 A-allele variant and GG homozygotes.

Methods

Baseline clinical data were collected during their initial visits. Disease severity was assessed using the UPDRS-III scale, while cognitive status was evaluated through the MMSE scale. Follow-up visits were conducted at the same center. Linear mixed-effects models were utilized to compare the rate of changes in motor and cognitive features between the two groups.

Results

A total of 18

SUBMITTER: Xu HL 

PROVIDER: S-EPMC12040838 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature