Health economic evaluation of newborn hepatitis B immunization prevention strategies in Ningbo: a Markov modeling study.

ABSTRACT:

Background

Hepatitis B virus (HBV) infection poses a significant public health challenge in China. The Prevention of mother-to-child Transmission (PMTCT) strategy of combining universal hepatitis B vaccination with hepatitis B immunoglobulin (HBIG) for newborns is crucial in preventing widespread infection. In this study, we conduct health economic evaluation of three strategies: PMTCT, universal vaccination, and non-vaccination for newborns in Ningbo, China.

Methods

This study developed a decision-Markov model and simulated a cohort of 100,000 newborns to assess the cost-effectiveness and cost-benefit of three strategies from a healthcare system perspective. The primary outputs included total costs, life-years (LYs), quality-adjusted life-years (QALYs), incremental cost-eff

SUBMITTER: Feng W 

PROVIDER: S-EPMC12040845 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature