Machine learning for prognostic impact in elderly unresectable hepatocellular carcinoma undergoing radiotherapy.

ABSTRACT:

Background/aim

This study develops a machine learning-based predictive model to evaluate the survival outcomes of elderly patients with unresectable hepatocellular carcinoma (HCC) undergoing radiotherapy.

Methods

The 2377 patients from SEER database were divided into training and internal validation cohorts. Additionally, 99 patients from our hospital were used for an external validation cohort. In the training cohort, 101 machine learning-based radiomics models were developed, and the optimal model's performance was subsequently evaluated in both the internal and external validation cohorts.

Results

The StepCox + GBM model demonstrated the highest C-index of 0.7 in the training cohort. The model was further evaluated using area under the receiver operating characteri

SUBMITTER: Shi Y 

PROVIDER: S-EPMC12040856 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature