Regulatory element map of sheep reproductive tissues: functional annotation of tissue-specific strong active enhancers.

ABSTRACT:

Introduction

Comprehensive functional annotation of the genome is crucial for elucidating the molecular mechanisms underlying complex traits and diseases. Although functional annotation has been partially completed in sheep, a systematic annotation focused on reproductive tissues remains absent.

Methods

In this study, we integrated 60 transcriptomic and epigenomic datasets from five reproductive tissues. Using a multi-omics approach, we predicted 15 distinct chromatin states and conducted thorough functional annotation.

Results

We established the first regulatory element atlas for sheep reproductive tissues and examined the roles of these elements in reproductive traits and disease. In total, we annotated 1,680,172 regulatory elements, including 83,980 tissue-specific

SUBMITTER: Meng Z 

PROVIDER: S-EPMC12040938 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature