Analysis of the senescence secretome during zebrafish retina regeneration.

ABSTRACT:

Introduction

Zebrafish possess the innate ability to regenerate any lost or damaged retinal cell type with Müller glia serving as resident stem cells. Recently, we discovered that this process is aided by a population of damage-induced senescent immune cells. As part of the Senescence Associated Secretory Phenotype (SASP), senescent cells secrete numerous factors that can play a role in the modulation of inflammation and remodeling of the retinal microenvironment during regeneration. However, the identity of specific SASP factors that drive initiation and progression of retina regeneration remains unclear.

Materials and methods

We mined the SASP Atlas and publicly available RNAseq datasets to identify common, differentially expressed SASP factors after retina injury. These d

SUBMITTER: Konar GJ 

PROVIDER: S-EPMC12040975 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature