From pixels to prognosis: leveraging radiomics and machine learning to predict IDH1 genotype in gliomas.

ABSTRACT: Gliomas are the most common primary tumors of the central nervous system, and advances in genetics and molecular medicine have significantly transformed their classification and treatment. This study aims to predict the IDH1 genotype in gliomas using radiomics and machine learning (ML) methods. Retrospective data from 108 glioma patients were analyzed, including MRI data supported by demographic details such as age, sex, and comorbidities. Tumor segmentation was manually performed using 3D Slicer software, and 112 radiomic features were extracted with the PyRadiomics library. Feature selection using the mRMR algorithm identified 17 significant radiomic features. Various ML algorithms, including KNN, Ensemble, DT, LR, Discriminant and SVM, were applied to predict the IDH1 genotype. The KNN

SUBMITTER: Karakas AB 

PROVIDER: S-EPMC12040993 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature