The aldehyde dehydrogenase superfamilies: correlations and deviations in structure and function.

ABSTRACT: Aldehyde dehydrogenases participate in many biochemical pathways, either by degrading organic substrates via organic acids or by producing reactive aldehyde intermediates in many biosynthetic pathways, and are becoming increasingly important for constructing synthetic metabolic pathways. Although they consist of simple and highly conserved basic structural motifs, they exhibit a surprising variability in the reactions catalyzed. We attempt here to give an overview of the known enzymes of two superfamilies comprising the known aldehyde dehydrogenases, focusing on their structural similarities and the residues involved in the catalytic reactions. The analysis reveals that the enzymes of the two superfamilies share many common traits and probably have a common evolutionary origin. While all e

SUBMITTER: Heider J 

PROVIDER: S-EPMC12041015 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature