COVID-19 mRNA-1273 vaccination induced mast cell activation with strongly elevated Th₂ cytokines in a systemic mastocytosis patient.

ABSTRACT:

Objective and design

SARS-CoV-2 vaccines are recommended for mastocytosis patients. We describe clinical symptoms, chemokine, cytokine, metabolomic and lipidomic derangements in a systemic mastocytosis patient following mRNA-1273 booster vaccination.

Methods

Twenty-eight chemokines and cytokines, 41 amino acids and 16 lipid classes were quantified with state-of-the-art methods.

Results

Mast cell activation (MCA) symptoms started 24 h after the mRNA-1273 booster vaccination with significant metabolic, lipidomic and cytokine derangements. Histamine concentrations peaked at life-threatening 18 ng/ml concomitant with high tryptase. Peak plasma IL-1Ra, IL-5, IL-6, IL-10, IL-11, CXCL10 and GM-CSF concentrations were elevated 54-, 4.9-, 85-, 54-, 6.1-, 19- and 6.4-fold respe

SUBMITTER: Weiss-Tessbach M 

PROVIDER: S-EPMC12041034 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature