Spatial mapping of the AA-PGE₂-EP axis in multiple sclerosis lesions.

ABSTRACT: Bioactive lipid mediators (LMs) derived from polyunsaturated fatty acids (PUFAs) are key molecules in both the initiation and resolution of inflammatory responses. Previous findings suggest that a dysregulated LM balance, especially within the arachidonic acid (AA) pathway, may contribute to an impaired resolution response and subsequent chronic neuroinflammation in multiple sclerosis (MS). However, to date, the local biosynthesis and signaling of LMs within the brain of people with MS (PwMS) remains unexplored. In this study, we, therefore, mapped the distribution of AA and its key downstream LM prostaglandin E₂ (PGE₂) in white matter MS brain tissue and of non-neurological controls (NNCs) for the first time using mass spectrometry imaging. We found that AA levels ar

SUBMITTER: Hansen CE 

PROVIDER: S-EPMC12041062 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature