Causal effect between telomere length and thirteen types of cancer in Asian population: a bidirectional Mendelian randomization study.

ABSTRACT:

Background

The relationship between leukocyte telomere length (LTL) and the risk of developing various cancers has always been controversial and predominantly focused on European populations. Hence, Mendelian randomization (MR) was applied to the Asian population to explore the causal relationships between LTL and the risk of developing various cancers.

Methods

We explored the causal connection between LTL and the risk of developing thirteen types of cancer in Asian populations using freely available genetic variation data. The primary analytical method employed was the inverse variance weighted (IVW) method, complemented by sensitivity and validation analyses. Following Bonferroni correction, P < 0.0038 was considered to indicate statistical significance, and P values rangi

SUBMITTER: Yang B 

PROVIDER: S-EPMC12041116 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature