Volume Kinetics of Gelofusine 4% During Vascular Surgery.

ABSTRACT:

Objectives

The volume kinetics of a commercially available colloid fluid, Gelofusine, have not been studied previously.

Methods

Intravenous Gelofusine 10 mL/kg was infused over 30 min in 15 patients undergoing vascular surgery. Of the 15 patients, 14 were classified as American Society of Anesthesiologists (ASA) class III status. The distribution and elimination of the infused volume was calculated with mixed-model kinetics based on 280 measurements of the hemoglobin-derived plasma dilution (19 per patient) collected over 180 min.

Results

The expanded central fluid space volume (V_c, the plasma) amounted to 2.16 L (95% confidence interval [CI] 1.06-2.35) at baseline. The maximum volume expansion of V_c was 706 mL (95% CI 599-812) after infusing Gel

SUBMITTER: Balan C 

PROVIDER: S-EPMC12041138 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature