Neurocognitive function in lower grade glioma patients selected for proton radiotherapy: real-world data from a prospective cohort study.

ABSTRACT:

Purpose

To determine neurocognitive function (NCF) profiles of patients with lower grade glioma (LGG) eligible to undergo proton radiotherapy (PRT), and how these relate to clinical and radiological characteristics. PRT is offered to those patients for whom sparing of NCF is considered important given their favorable prognosis. To date it is unknown to which extent their NCF profiles are favorable as well.

Methods

A consecutive cohort of 151 LGG patients eligible for PRT according to prevailing Dutch criteria, referred between 2018 and 2023, were assessed with standardized neuropsychological tests prior to PRT. Scores were compared to norm-scores. Composite scores were calculated for the total NCF and 6 separate cognitive domains, and profiles were related to tumor location.

SUBMITTER: van der Weide HL 

PROVIDER: S-EPMC12041185 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature