Transparent, metal-free PEDOT:PSS neural interfaces for simultaneous recording of low-noise electrophysiology and artifact-free two-photon imaging.

ABSTRACT: Simultaneous two-photon imaging and electrophysiological recordings offer considerable potential for advancing neurological research and therapies. However, traditional metal-based neural interfaces suffer from photoelectric artifacts, while existing transparent implants rely on opaque interconnect lines to address conductivity limitations. Herein, we developed an optically transparent poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) neural electrode array with transparent electrodes and interconnect lines. Through a formamide, phosphoric acid, and ethylene glycol treatment, the metal-free PEDOT:PSS array achieved an impedance of 45.8 kΩ (at 1 kHz) even with a 20 × 20 µm² size. This advanced performance surpasses previous metal-free transparent neural interfaces and facil

SUBMITTER: Kim HW 

PROVIDER: S-EPMC12041238 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature