Liver transplant-facilitated CD161⁺Vα7.2⁺ MAIT cell recovery demonstrates clinical benefits in hepatic failure patients.

ABSTRACT: Mucosal-associated invariant T (MAIT) cells exert multifaceted effects such as anti-microbial activity, tissue repair, and pro-fibrotic effects across various disease settings. Nonetheless, their role in liver injury and hemostasis remains debated. Here, we report a significant depletion and functional dysregulation of MAIT cells, which is associated with disease severity and accumulated bile acids in HBV-infected patients with varying degree of liver injury. Liver transplantation facilitates a gradual recovery of recipient-originated MAIT cells. Transcriptome analysis reveals enhanced MAIT cell activation, while TCR mining demonstrates clonotype overlap between circulating and hepatic MAIT cells during significant liver injury. TCR-activated MAIT cells from transplant recipients display h

SUBMITTER: Wang W 

PROVIDER: S-EPMC12041255 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature