High-fat diet and chronic restraint stress exacerbate anxiety-depressive behaviors via astrocytic A1 phenotype transformation.

ABSTRACT: Obesity and depression are likely to co-occur. However, there are few reports on the relationship between obesity and depression. We aimed to investigate the effect of high-fat diet combined with chronic restraint stress on depressive-like behaviors, focusing on the phenotypic transformation of astrocytes. Male C57BL/6 mice were randomly divided into four equal groups: control, high-fat diet (HFD), chronic restraint stress (CRS) and HFD + CRS groups. They were subjected to an 8-week high-fat diet and 3-week restraint stress stimulation. In vitro, palmitic acid (PA) and corticosterone (Cort) were used to mimic HFD and CRS respectively on C8-D1A astrocytes. Our results showed that HFD aggravates anxiety and depression-like behaviors and learning and memory deficits induced by CRS, as reflect

SUBMITTER: Ding R 

PROVIDER: S-EPMC12041363 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature