Identification of immune phenotypes and diagnostic biomarkers in active and latent tuberculosis infections.

ABSTRACT: The diagnosis and treatment of tuberculosis rely on a deep understanding of the pathobiology and immune responses. This study aimed to identify potential immune response mechanisms by integrating gene expression analysis with immune cell distribution profiling to characterize the immune phenotypes of active tuberculosis (ATB) and latent tuberculosis infection (LTB). Differentially expressed genes (DEGs) between ATB or LTB and controls were identified using the GSE19491 and GSE107994 datasets. A total of 273 and 105 immune-related DEGs were identified in ATB and LTB through ImmProt database, respectively. Immune-related DEGs specific to LTB were mainly enriched in the MAPK signaling pathway, Ras signaling pathway. Furthermore, random forest analysis identified HLA-DRB5 and IRF1 as showing d

SUBMITTER: Shao T 

PROVIDER: S-EPMC12041371 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature