Correlation study of PBK/TOPK expression, prognosis, and immune infiltration in breast cancer.

ABSTRACT: PDZ-binding kinase/T-lymphokine-activated killer-cell-originated protein kinase (PBK/TOPK) is a serine-threonine protein kinase. This study aimed to investigate the expression pattern, prognostic significance, and relationship with tumor immune infiltration of PBK/TOPK in breast cancer through bioinformatics analyses and immunohistochemistry (IHC), providing insights for individualized treatment and immunotherapy strategies. PBK/TOPK expression and its correlation with clinicopathological features were analyzed using TIMER, UALCAN, and TCGA databases. Prognostic value was assessed via Kaplan-Meier plotter and bc-GenExMiner. Variants of the PBK/TOPK gene and their prognostic implications were explored using cBioPortal. Enrichment analysis in R identified signaling pathways linked to PBK/TOP

SUBMITTER: Li B 

PROVIDER: S-EPMC12041462 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature