Differential cellular origins of the extracellular matrix of tumor and normal tissues according to colorectal cancer subtypes.

ABSTRACT:

Background

Understanding the proteomic-level heterogeneity of the tumor microenvironment (TME) in colorectal cancer (CRC) is crucial due to its well-known heterogeneity. While heterogenous CRC has been extensively characterized at the molecular subtype level, research into the functional heterogeneity of fibroblasts, particularly their relationship with extracellular matrix (ECM) alterations, remains limited. Addressing this gap is essential for a comprehensive understanding of CRC progression and the development of targeted therapies.

Methods

24 tissue samples from 21 CRC patients, along with adjacent normal tissues (NAT), were collected and decellularized using a detergent-based method to enrich the ECM component. Proteomic analysis of ECM-enriched samples was performed us

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC12041468 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature