Effects of <i>Malassezia globosa</i> on the Expression of Thymic Stromal Lymphopoietin and Differentiation of T Helper Cells in MC903-Induced Atopic Dermatitis Mouse Model.

ABSTRACT: Atopic dermatitis (AD) is a chronic and inflammatory disease with an immunogenetic basis that can be triggered by extrinsic and intrinsic factors, including dysbiosis of the skin microbiota. The lipophilic Malassezia globosa is one of the dominant fungal species on the skin of AD patients. Malassezia and the host pathophysiologic mechanism underlying its role in exacerbating AD symptoms remain to be elucidated. This experiment established a fungal overgrowth model by topical administration suspension of M. globosa on BALB/c mice (M group) and MC903-induced AD model (AD+M group). Our results suggested that more severe AD-like lesions and higher dermatitis scoring were observed in the AD+M group compared with the AD group. The expression of TSLP mRNA in the tissue and se

SUBMITTER: Zhou X 

PROVIDER: S-EPMC12041643 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature