Monitoring complete hydatidiform molar pregnancies after normalisation of human chorionic gonadotrophin: national retrospective population study.

ABSTRACT:

Objective

To provide evidence for a reduced surveillance protocol to detect gestational trophoblastic neoplasia after normalisation of human chorionic gonadotrophin (hCG) levels following uterine evacuation of a complete hydatidiform mole.

Design

National retrospective population study.

Setting

Two UK Trophoblastic Disease Treatment Centres (Sheffield and London), 1 January 1980 to 30 November 2020.

Participants

17 424 patients with hCG normalisation after evacuation of their complete hydatidiform mole were included. Complete hydatidiform moles were verified by centralised pathological review. Patients were excluded if lost to follow-up or required treatment before normalisation of hCG levels.

Main outcome measures

Incidence and clinical presentation of

SUBMITTER: Swift BE 

PROVIDER: S-EPMC12041671 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature